Take what the draft gives you. If the top 4 running backs are on the board when you're up, take one of them. If not, go for Manning or a top receiver maybe. You could take graham if you wanted. After that just fill your roster with the best players the draft gives you at running back and receiver. If you didn't get a top 3 QB, you can get a decent one like cutler and Matt Ryan late in the draft and they both have upside. Also if you don't get a top tight end, wait until the later rounds because all tight ends after gronk and graham aren't very different from each other. Ertz is a good sleeper tight end. Also, kickers and defenses last 2 rounds. You don't really need a backup tight end and you only need a backup QB if you don't get a top 3 QB. Hope this helps!
depends on league scoring system and how rosters are built/how deep the roster is. Generally, unless it is a 2 QB league, you can wait on a QB and fill the RB/WR positions equally through the first four rounds.Unless you get Jimmy Graham, you can wait on a tight end. Get your QB in rounds 6,7,8 then fill in roster with solid receivers and upside running backs. Late rounds are for deep sleepers and handcuffs of RB you have. Defenses and kickers should be taken in last two rounds. I stream defenses, using week to week match ups to get my Dee for the week.